Surgical Sealants And Adhesives

Surgical Sealants And Adhesives Market Outlook

The global surgical sealants and adhesives market is projected to reach USD 4.7 billion by 2025, growing at a compound annual growth rate (CAGR) of approximately 8.4% from 2025 to 2035. This significant growth can be attributed to the rising number of surgical procedures globally, advancements in healthcare infrastructure, and increasing demand for minimally invasive surgeries. Furthermore, an aging population that is more prone to chronic diseases and surgical interventions is contributing to the market's expansion. The increased focus on patient safety and the benefits of using sealants over traditional sutures and staples are further propelling the growth of this market. Innovations in product formulations and increased awareness about the benefits of surgical sealants are also key factors driving market growth.

Growth Factor of the Market

The surgical sealants and adhesives market is driven by multiple growth factors that bolster its advancement. One of the primary factors is the growing prevalence of chronic diseases requiring surgical interventions, which fuels the demand for sealants and adhesives. Moreover, the increase in elective surgeries due to rising disposable incomes is also a significant contributor to market growth. Another notable factor is the technological advancements in the development of innovative sealants that offer improved efficacy and safety profiles. Additionally, the rising geriatric population, who are more susceptible to surgical conditions, is creating a larger market base for surgical sealants and adhesives. The trend towards minimally invasive surgical techniques further enhances the market outlook, as these techniques often rely on the effective application of sealants and adhesives for optimal outcomes. Finally, the growing emphasis on wound healing and patient recovery drives healthcare professionals to adopt advanced sealing solutions.

Key Highlights of the Market

• Projected market size of USD 4.7 billion by 2025 with a CAGR of 8.4%.
• Increasing number of surgical procedures and rising demand for minimally invasive techniques.
• Technological advancements leading to innovative and more efficient sealant products.
• Growing elderly population, particularly in developed regions.
• Focus on patient safety and improved patient outcomes driving adoption.

By Product Type

Natural Surgical Sealants:

Natural surgical sealants are derived from biological sources and have gained popularity due to their biocompatibility and biodegradability. These sealants, which can be formulated from materials such as fibrin or collagen, are increasingly used in a variety of surgical applications, including vascular and orthopedic surgeries. The ability of natural sealants to promote tissue healing and reduce the risk of infection contributes to their growing adoption. Moreover, because of their natural origins, they are less likely to elicit adverse reactions in patients, making them a preferred choice for many surgeons. The increasing trend towards using biologically-based products in healthcare settings amplifies the demand for natural surgical sealants in the market.

Synthetic Surgical Sealants:

Synthetic surgical sealants have emerged as a robust segment within the market, primarily due to their versatility and the ability to tailor their properties for specific surgical needs. These sealants are designed to offer enhanced adhesion and mechanical strength compared to their natural counterparts. The growing prevalence of advanced surgical procedures and the necessity for reliable sealing mechanisms contribute to the increased utilization of synthetic sealants. Additionally, advancements in synthetic polymer chemistry have led to the development of innovative sealants that can address a range of medical applications. Their ease of use and capability for rapid application in the operating room further enhance their attractiveness among healthcare professionals.

Fibrin Sealants:

Fibrin sealants have gained significant traction due to their strong adhesion properties, which emulate the natural clotting process. This category of sealants is extensively used in surgical procedures, especially in vascular, orthopedic, and cardiac surgeries. The ability of fibrin sealants to promote hemostasis and tissue healing makes them an invaluable asset in surgical settings. Moreover, the focus on patient safety and minimizing complications post-surgery has driven the adoption of fibrin sealants. The regulatory approvals and ongoing research into their efficacy and quality further contribute to the growing segment of fibrin sealants in the surgical sealants and adhesives market.

Collagen Sealants:

Collagen sealants are another crucial type of surgical sealant that is gaining popularity due to their biocompatibility and ability to promote wound healing. These sealants are derived from collagen, a natural protein that plays a vital role in tissue repair. The utilization of collagen sealants is particularly prominent in reconstructive surgeries and wound management applications. Their ability to integrate with the surrounding tissue enhances their effectiveness in promoting successful healing outcomes. With ongoing research into the optimization of collagen formulations, this segment is expected to witness steady growth in the coming years.

Gelatin Sealants:

Gelatin sealants are characterized by their ease of use and rapid application, making them a preferred choice in various surgical procedures. These sealants are primarily composed of gelatin, which is derived from collagen, providing a strong adhesive bond that promotes hemostasis. The use of gelatin sealants is notable in surgeries requiring quick sealing solutions, such as in trauma care or elective procedures. The increasing awareness of the benefits of gelatin sealants, such as their affordability and effectiveness, is driving their adoption in surgical settings. Additionally, ongoing research into enhancing their performance and expanding their applications is expected to support the growth of gelatin sealants in the market.

By Application

Tissue Sealing:

Tissue sealing is a significant application area for surgical sealants, as these products are essential for closing incisions and wounds during surgical procedures. The need for effective sealing solutions has grown with the rise in surgical procedures globally. Surgical sealants used in tissue sealing not only provide a barrier against infections but also minimize blood loss and promote faster healing. The increasing focus on patient safety and the avoidance of complications such as leakage or infection drives the demand for reliable tissue sealing solutions, contributing to the market's growth. Additionally, as advanced surgical techniques continue to evolve, the importance of innovative sealing products in achieving optimal surgical outcomes becomes increasingly apparent.

Tissue Engineering:

Tissue engineering represents a novel application for surgical sealants, particularly in regenerative medicine and complex surgical repairs. Sealants facilitate the adhesion of engineered tissues to host tissues, ensuring successful integration and functionality. The growing field of tissue engineering is significantly bolstered by advancements in biomaterials and the development of sealants that support cellular activities and tissue regeneration. The increasing prevalence of tissue engineering applications in orthopedic, cardiac, and reconstructive surgeries is also driving demand for specialized sealants that can meet the unique challenges in these applications. Ongoing research and innovation in this sector are likely to enhance the adoption of sealants in tissue engineering.

Hemostasis:

Hemostasis is one of the primary applications of surgical sealants and adhesives, playing a critical role in controlling bleeding during surgical procedures. The increasing number of surgeries, coupled with the emphasis on minimizing blood loss, has significantly driven the demand for hemostatic sealants. These products are engineered to provide rapid and effective sealing capabilities, helping surgeons achieve hemostasis quickly and efficiently. As advancements in surgical techniques, particularly in minimally invasive procedures, continue to evolve, the need for effective hemostatic solutions remains paramount. Moreover, the growing focus on patient outcomes and recovery times drives investment in innovative hemostatic sealants that can meet the rigorous demands of modern surgical practices.

Others:

In addition to the predominant applications of tissue sealing, tissue engineering, and hemostasis, there are several other applications where surgical sealants and adhesives play a vital role. These include wound care management, cosmetic surgeries, and various veterinary applications. As medical technology advances, the versatility of sealants enables their use in a broader range of clinical scenarios, expanding market opportunities. The ongoing development and approval of specialized sealants for unique applications further enhance the growth potential of the market. As healthcare providers continue to explore the benefits of these products, it is expected that the 'other' application segment will gain traction in the coming years.

By Distribution Channel

Hospitals:

Hospitals represent the primary distribution channel for surgical sealants and adhesives, owing to the substantial volume of surgical procedures conducted in these settings. Hospitals generally have comprehensive surgical departments equipped with advanced technology and skilled healthcare professionals, making them key consumers of surgical sealants. The increasing number of surgeries being performed, coupled with an emphasis on patient safety and optimal surgical outcomes, drives the demand for high-quality sealants in hospital settings. Moreover, hospitals often procure these products in bulk, leading to favorable purchasing agreements with manufacturers. The rise in specialized surgical centers within hospitals also contributes to the growing market for surgical sealants in these institutions.

Specialty Clinics:

Specialty clinics have emerged as a growing distribution channel for surgical sealants and adhesives, particularly as the healthcare landscape evolves towards more specialized care. These clinics often focus on specific areas such as orthopedics, plastic surgery, or wound care, providing tailored services that require specialized sealants. The increasing number of outpatient surgeries performed in these clinics creates a demand for effective sealing solutions that can enhance patient outcomes. The trend towards minimally invasive surgical procedures in these settings is also driving the need for innovative sealants that provide efficient sealing without compromising safety. As the number of specialty clinics continues to rise, their role as significant consumers in the surgical sealants market will likely increase.

Ambulatory Surgical Centers:

Ambulatory surgical centers (ASCs) are becoming an increasingly important distribution channel for surgical sealants and adhesives due to the rising trend of outpatient surgeries. These centers are designed to perform surgeries that do not require hospitalization, leading to a significant increase in the volume of procedures conducted in this setting. The demand for efficient and rapid sealing solutions is paramount in ASCs, where quick recovery and discharge of patients are prioritized. As the healthcare system moves towards value-based care, ASCs are leveraging surgical sealants to enhance patient outcomes and reduce complication rates. This growing trend towards outpatient surgeries will continue to bolster the demand for surgical sealants within ambulatory surgical centers.

Others:

In addition to hospitals, specialty clinics, and ambulatory surgical centers, there are other distribution channels for surgical sealants and adhesives that play a pivotal role in the market. These may include online platforms, medical supply distributors, and pharmacies. The rise of e-commerce in the healthcare sector has opened new avenues for distributing surgical sealants, providing healthcare professionals with convenient access to a range of products. Furthermore, partnerships with medical supply distributors help manufacturers reach various healthcare providers effectively. As the market matures, the 'others' distribution channel will likely experience increased significance, driven by the demand for accessibility and convenience in procuring surgical products.

By Ingredient Type

Cyanoacrylate:

Cyanoacrylate is a widely used ingredient in surgical sealants, known for its rapid curing properties and strong adhesive strength. This compound is particularly popular in minimally invasive procedures, where quick sealing is essential to reduce the risk of complications. The high adhesive strength of cyanoacrylate makes it effective for various applications, including skin closure and internal suturing. Its ability to bond quickly not only enhances surgical efficiency but also improves patient comfort by minimizing exposure to longer surgical procedures. The growing adoption of cyanoacrylate-based sealants in various surgical applications is expected to contribute significantly to the segment's growth in the surgical sealants and adhesives market.

Polyethylene Glycol:

Polyethylene glycol (PEG) is increasingly recognized for its biocompatibility and versatility in formulating surgical sealants. As a synthetic polymer, PEG offers unique properties that enable it to effectively perform in various surgical environments. Its hydrophilic nature facilitates a strong bond with biological tissues, making it an ideal choice for applications requiring tissue adhesion. The growing trend toward using biocompatible materials in surgical settings further enhances the demand for PEG-based sealants. Additionally, ongoing research into optimizing PEG formulations for specific surgical applications promises to propel this ingredient type's growth in the surgical sealants market.

Albumin:

Albumin is a naturally occurring protein that has found significant utility in surgical sealants due to its biocompatibility and safety profile. Its use in surgical adhesives is primarily for tissue adhesion and promoting wound healing. The increasing awareness of the benefits of utilizing biologically derived components in surgical procedures is driving the adoption of albumin-based sealants. Moreover, as hospitals and clinicians continue to prioritize patient safety, the demand for albumin as an ingredient in surgical sealants is expected to rise. The segment's growth is further supported by research into the formulation of albumin-based sealants for specialized applications, enhancing their relevance in the market.

Fibrin:

Fibrin serves as a crucial ingredient in numerous surgical sealants, especially those designed to promote hemostasis and tissue healing. Derived from fibrinogen, this protein provides a natural solution for sealing wounds and incisions during surgical procedures. The increasing preference for biologically active components in surgical adhesives drives the uptake of fibrin-based sealants, particularly in applications requiring tissue adhesion and repair. Fibrin sealants are often preferred for their ability to mimic natural clotting processes, reducing recovery times and complications. Consequently, the segment of fibrin-based sealants is projected to experience robust growth, fueled by ongoing advancements in surgical techniques and increased surgical volume.

By Region

The North American region is poised to dominate the surgical sealants and adhesives market, driven by advanced healthcare infrastructure, high healthcare spending, and a significant volume of surgical procedures performed annually. According to market estimates, North America holds approximately 45% of the global market share. The region's emphasis on patient safety, coupled with the increasing adoption of advanced surgical techniques, contributes to the strong demand for innovative sealing solutions. The CAGR for North America is projected to be around 8.2%, reflecting the growing focus on minimally invasive surgeries and enhanced patient outcomes.

In Europe, the market for surgical sealants and adhesives is also expected to witness substantial growth, driven by the rising number of surgical interventions and technological advancements in the healthcare sector. The European market holds around 30% of the global market share, with a projected CAGR of approximately 7.5%. Factors such as an aging population, increased prevalence of chronic diseases, and growing awareness about the benefits of surgical sealants are driving demand in this region. The market is further bolstered by government initiatives aimed at improving healthcare standards and supporting research and development in medical technology.

Opportunities

The surgical sealants and adhesives market presents numerous opportunities as healthcare continues to evolve. One significant opportunity lies in the development of advanced adhesive formulations that cater to the specific needs of various surgical specialties. As the demand for personalized medicine grows, manufacturers can focus on creating tailored sealants that enhance surgical outcomes for specific procedures and patient populations. Additionally, the rise in outpatient surgeries and minimally invasive techniques offers a vast market potential for innovative sealants designed for rapid application and effectiveness. Furthermore, collaborations with healthcare providers and research institutions can lead to clinical trials that validate the efficacy of new products, creating opportunities for market expansion.

Another promising area for growth is the increasing focus on wound healing and management, particularly in the context of chronic wounds and surgical site infections. As the global healthcare landscape shifts towards value-based care, there is a growing emphasis on improving patient outcomes through effective sealing solutions. Manufacturers who invest in research and development to create sealants with advanced healing properties can capitalize on this trend. Additionally, expansion into emerging markets where healthcare infrastructure is improving presents significant growth opportunities for the surgical sealants and adhesives market. Increased awareness and access to advanced surgical technologies in these regions are likely to drive demand for innovative sealing solutions.

Threats

Despite the promising growth trajectory, the surgical sealants and adhesives market faces several threats that could impede progress. One of the primary concerns is the stringent regulatory landscape governing the approval and commercialization of medical devices. Manufacturers must navigate complex approval processes that can delay product launches and increase development costs. Additionally, the risk of product recalls due to safety or efficacy concerns poses a significant threat to companies operating in this market. The presence of alternative wound closure methods, such as sutures and staples, also presents competitive pressure, as some healthcare providers may opt for traditional methods over newer sealing technologies. Moreover, ongoing economic fluctuations can impact healthcare spending, influencing hospitals' purchasing decisions and potentially constraining market growth.

Another threat to the surgical sealants and adhesives market is the potential for adverse reactions and complications associated with certain products. While advancements in sealant technology have improved safety, there is still a risk of allergic reactions or infections linked to some sealants. Such incidents can lead to increased scrutiny from regulatory bodies and diminish consumer trust in these products. Additionally, the growing awareness of cost-effective healthcare solutions may prompt healthcare facilities to seek more economical alternatives to surgical sealants, impacting overall market dynamics. Manufacturers must remain vigilant and address these risks to maintain their competitive positioning in the marketplace.

Competitor Outlook

• Baxter International Inc.
• Johnson & Johnson
• Medtronic plc
• 3M Company
• BSN Medical
• FzioMed, Inc.
• Hemostasis, LLC
• Sealantis Ltd.
• Ethicon Inc.
• Adhezion Biomedical, LLC
• DeRoyal Industries, Inc.
• Omnigraft
• Quinnova Medical, Inc.
• Coloplast A/S
• Smith & Nephew plc

The competitive landscape of the surgical sealants and adhesives market is characterized by the presence of several key players who are actively engaged in research, development, and commercialization of innovative products. Companies such as Baxter International Inc. and Johnson & Johnson have established themselves as leaders in this market, leveraging their extensive product portfolios and global distribution networks. These organizations continuously invest in R&D to enhance product offerings and address the evolving needs of healthcare providers and patients. Their focus on innovation, coupled with a commitment to quality and safety, has positioned them favorably in the competitive landscape.

Medtronic plc and 3M Company are also significant players in the market, known for their advanced surgical technologies and diverse range of sealants and adhesives. Medtronic's expertise in minimally invasive surgical solutions has led to the development of specialized sealants that enhance patient outcomes. Similarly, 3M's commitment to innovation in wound care and surgical solutions drives their competitive positioning. Both companies are actively involved in strategic partnerships and collaborations to expand their market reach and participate in emerging growth opportunities.

Emerging companies such as FzioMed, Inc. and Sealantis Ltd. are making notable strides in the market by introducing innovative sealant formulations tailored for specific surgical applications. These companies often focus on niche markets, providing specialized solutions that meet unique surgical challenges. Their agility and ability to respond to market demands enable them to carve out a competitive advantage in the surgical sealants and adhesives market. As the market continues to evolve, the competitive landscape will likely see increased consolidation and collaboration among players seeking to enhance their product offerings and market presence.

• 1 Appendix

  • 1.1 List of Tables
  • 1.2 List of Figures

• 2 Introduction

  • 2.1 Market Definition
  • 2.2 Scope of the Report
  • 2.3 Study Assumptions
  • 2.4 Base Currency & Forecast Periods

• 3 Market Dynamics

  • 3.1 Market Growth Factors
  • 3.2 Economic & Global Events
  • 3.3 Innovation Trends
  • 3.4 Supply Chain Analysis

• 4 Consumer Behavior

  • 4.1 Market Trends
  • 4.2 Pricing Analysis
  • 4.3 Buyer Insights

• 5 Key Player Profiles

  • 5.1 Omnigraft
    • 5.1.1 Business Overview
    • 5.1.2 Products & Services
    • 5.1.3 Financials
    • 5.1.4 Recent Developments
    • 5.1.5 SWOT Analysis
  • 5.2 3M Company
    • 5.2.1 Business Overview
    • 5.2.2 Products & Services
    • 5.2.3 Financials
    • 5.2.4 Recent Developments
    • 5.2.5 SWOT Analysis
  • 5.3 BSN Medical
    • 5.3.1 Business Overview
    • 5.3.2 Products & Services
    • 5.3.3 Financials
    • 5.3.4 Recent Developments
    • 5.3.5 SWOT Analysis
  • 5.4 Ethicon Inc.
    • 5.4.1 Business Overview
    • 5.4.2 Products & Services
    • 5.4.3 Financials
    • 5.4.4 Recent Developments
    • 5.4.5 SWOT Analysis
  • 5.5 Coloplast A/S
    • 5.5.1 Business Overview
    • 5.5.2 Products & Services
    • 5.5.3 Financials
    • 5.5.4 Recent Developments
    • 5.5.5 SWOT Analysis
  • 5.6 FzioMed, Inc.
    • 5.6.1 Business Overview
    • 5.6.2 Products & Services
    • 5.6.3 Financials
    • 5.6.4 Recent Developments
    • 5.6.5 SWOT Analysis
  • 5.7 Medtronic plc
    • 5.7.1 Business Overview
    • 5.7.2 Products & Services
    • 5.7.3 Financials
    • 5.7.4 Recent Developments
    • 5.7.5 SWOT Analysis
  • 5.8 Sealantis Ltd.
    • 5.8.1 Business Overview
    • 5.8.2 Products & Services
    • 5.8.3 Financials
    • 5.8.4 Recent Developments
    • 5.8.5 SWOT Analysis
  • 5.9 Hemostasis, LLC
    • 5.9.1 Business Overview
    • 5.9.2 Products & Services
    • 5.9.3 Financials
    • 5.9.4 Recent Developments
    • 5.9.5 SWOT Analysis
  • 5.10 Johnson & Johnson
    • 5.10.1 Business Overview
    • 5.10.2 Products & Services
    • 5.10.3 Financials
    • 5.10.4 Recent Developments
    • 5.10.5 SWOT Analysis
  • 5.11 Smith & Nephew plc
    • 5.11.1 Business Overview
    • 5.11.2 Products & Services
    • 5.11.3 Financials
    • 5.11.4 Recent Developments
    • 5.11.5 SWOT Analysis
  • 5.12 Quinnova Medical, Inc.
    • 5.12.1 Business Overview
    • 5.12.2 Products & Services
    • 5.12.3 Financials
    • 5.12.4 Recent Developments
    • 5.12.5 SWOT Analysis
  • 5.13 Adhezion Biomedical, LLC
    • 5.13.1 Business Overview
    • 5.13.2 Products & Services
    • 5.13.3 Financials
    • 5.13.4 Recent Developments
    • 5.13.5 SWOT Analysis
  • 5.14 DeRoyal Industries, Inc.
    • 5.14.1 Business Overview
    • 5.14.2 Products & Services
    • 5.14.3 Financials
    • 5.14.4 Recent Developments
    • 5.14.5 SWOT Analysis
  • 5.15 Baxter International Inc.
    • 5.15.1 Business Overview
    • 5.15.2 Products & Services
    • 5.15.3 Financials
    • 5.15.4 Recent Developments
    • 5.15.5 SWOT Analysis

• 6 Market Segmentation

  • 6.1 Surgical Sealants And Adhesives Market, By Application
    • 6.1.1 Tissue Sealing
    • 6.1.2 Tissue Engineering
    • 6.1.3 Hemostasis
    • 6.1.4 Others
  • 6.2 Surgical Sealants And Adhesives Market, By Product Type
    • 6.2.1 Natural Surgical Sealants
    • 6.2.2 Synthetic Surgical Sealants
    • 6.2.3 Fibrin Sealants
    • 6.2.4 Collagen Sealants
    • 6.2.5 Gelatin Sealants
  • 6.3 Surgical Sealants And Adhesives Market, By Ingredient Type
    • 6.3.1 Cyanoacrylate
    • 6.3.2 Polyethylene Glycol
    • 6.3.3 Albumin
    • 6.3.4 Fibrin
  • 6.4 Surgical Sealants And Adhesives Market, By Distribution Channel
    • 6.4.1 Hospitals
    • 6.4.2 Specialty Clinics
    • 6.4.3 Ambulatory Surgical Centers
    • 6.4.4 Others

• 7 Competitive Analysis

  • 7.1 Key Player Comparison
  • 7.2 Market Share Analysis
  • 7.3 Investment Trends
  • 7.4 SWOT Analysis

• 8 Research Methodology

  • 8.1 Analysis Design
  • 8.2 Research Phases
  • 8.3 Study Timeline

• 9 Future Market Outlook

  • 9.1 Growth Forecast
  • 9.2 Market Evolution

• 10 Geographical Overview

  • 10.1 Europe - Market Analysis
    • 10.1.1 By Country
      • 10.1.1.1 UK
      • 10.1.1.2 France
      • 10.1.1.3 Germany
      • 10.1.1.4 Spain
      • 10.1.1.5 Italy
  • 10.2 Asia Pacific - Market Analysis
    • 10.2.1 By Country
      • 10.2.1.1 India
      • 10.2.1.2 China
      • 10.2.1.3 Japan
      • 10.2.1.4 South Korea
  • 10.3 Latin America - Market Analysis
    • 10.3.1 By Country
      • 10.3.1.1 Brazil
      • 10.3.1.2 Argentina
      • 10.3.1.3 Mexico
  • 10.4 North America - Market Analysis
    • 10.4.1 By Country
      • 10.4.1.1 USA
      • 10.4.1.2 Canada
  • 10.5 Middle East & Africa - Market Analysis
    • 10.5.1 By Country
      • 10.5.1.1 Middle East
      • 10.5.1.2 Africa
  • 10.6 Surgical Sealants And Adhesives Market by Region

• 11 Global Economic Factors

  • 11.1 Inflation Impact
  • 11.2 Trade Policies

• 12 Technology & Innovation

  • 12.1 Emerging Technologies
  • 12.2 AI & Digital Trends
  • 12.3 Patent Research

• 13 Investment & Market Growth

  • 13.1 Funding Trends
  • 13.2 Future Market Projections

• 14 Market Overview & Key Insights

  • 14.1 Executive Summary
  • 14.2 Key Trends
  • 14.3 Market Challenges
  • 14.4 Regulatory Landscape

Segments Analyzed in the Report

The global Surgical Sealants And Adhesives market is categorized based on

By Product Type

• Natural Surgical Sealants
• Synthetic Surgical Sealants
• Fibrin Sealants
• Collagen Sealants
• Gelatin Sealants

By Application

• Tissue Sealing
• Tissue Engineering
• Hemostasis
• Others

By Distribution Channel

• Hospitals
• Specialty Clinics
• Ambulatory Surgical Centers
• Others

By Ingredient Type

• Cyanoacrylate
• Polyethylene Glycol
• Albumin
• Fibrin

By Region

• North America
• Europe
• Asia Pacific
• Latin America
• Middle East & Africa

Key Players

• Baxter International Inc.
• Johnson & Johnson
• Medtronic plc
• 3M Company
• BSN Medical
• FzioMed, Inc.
• Hemostasis, LLC
• Sealantis Ltd.
• Ethicon Inc.
• Adhezion Biomedical, LLC
• DeRoyal Industries, Inc.
• Omnigraft
• Quinnova Medical, Inc.
• Coloplast A/S
• Smith & Nephew plc