Size Exclusion Chromatographic Columns

Size Exclusion Chromatographic Columns Market Outlook

The global size exclusion chromatographic columns market is projected to reach USD 2.15 billion by 2035, growing at a CAGR of 6.2% during the forecast period from 2025 to 2035. The increasing demand for advanced separation techniques in various industries, including pharmaceuticals, biotechnology, and food and beverage, is a primary growth driver for this market. Additionally, the rise in research activities and the growing focus on drug development processes are expected to further propel the adoption of size exclusion chromatography. Innovations in column technology, leading to improved performance and efficiency, are also contributing to market growth. Furthermore, the expansion of academic and research institutions globally is likely to enhance the market landscape.

Growth Factor of the Market

The growth of the size exclusion chromatographic columns market can be attributed to several factors that are revolutionizing the analytical landscape. One major factor is the increasing investments in research and development within the pharmaceutical and biotechnology sectors, which require precise and efficient separation methods for analysis and quality control. Moreover, the rising prevalence of chronic diseases has led to an uptick in drug development, demanding more advanced chromatography solutions to ensure product safety and efficacy. Furthermore, the food and beverage sector is also adopting size exclusion chromatography for quality assurance and compliance with stringent food safety regulations. The growing environmental concerns and the need for pollution monitoring are driving the implementation of chromatographic techniques in environmental analysis as well. The ongoing technological advancements in column materials and designs have resulted in more efficient, reproducible, and user-friendly products, further stimulating market growth.

Key Highlights of the Market

• Projected global market size of USD 2.15 billion by 2035.
• CAGR of 6.2% during the forecast period from 2025 to 2035.
• Significant application growth in pharmaceuticals and biotechnology sectors.
• Technological advancements leading to improved column efficiency and separation accuracy.
• Increasing demand for chromatographic solutions in food and beverage quality control.

By Product Type

Porous Columns :

Porous columns are a vital segment in the size exclusion chromatographic columns market, offering a unique advantage in separating biomolecules based on their size. These columns contain a porous stationary phase, allowing for the effective separation of substances ranging from small molecules to large proteins. The widespread application of porous columns in pharmaceutical and biotechnology industries is attributable to their efficiency in purifying biomolecules and ensuring high-resolution results. The demand for porous columns is also fueled by their ability to accommodate a wide range of sample sizes and concentrations, making them versatile tools in laboratory settings. As more organizations require reliable, reproducible results for their research, the adoption of porous columns is anticipated to grow significantly.

Gel Filtration Columns :

Gel filtration columns are another essential type of size exclusion chromatographic columns, specifically designed to separate molecules according to their size through a gel matrix. This type of column is particularly useful in biochemistry and molecular biology applications, where the separation of proteins, nucleic acids, and polysaccharides is critical. The rising demand for high-purity products in the pharmaceutical industry is driving the growth of gel filtration columns. Furthermore, advancements in gel technologies and materials are enhancing the performance and efficiency of these columns, ensuring their continued relevance in various research areas. Their ability to provide gentle separation, preserving the integrity of sensitive biomolecules, is a significant advantage that boosts their market position.

Monolithic Columns :

Monolithic columns represent a revolutionary advancement in the size exclusion chromatographic columns market. Unlike traditional packed columns, monolithic columns consist of a single piece of porous material, leading to reduced back pressure and enhanced flow rates. These characteristics make them particularly valuable in high-throughput applications, where efficiency and speed are paramount. The growing trend towards miniaturization and automation in laboratories further supports the adoption of monolithic columns, as they can accommodate smaller sample volumes without compromising separation quality. As researchers seek more efficient methodologies, monolithic columns are increasingly viewed as a viable alternative to conventional column technologies.

Packed Columns :

Packed columns have long been a staple in the chromatographic columns market due to their simplicity and effectiveness in separating a variety of compounds. These columns are filled with solid particles that create a stationary phase for separation processes. The packed column segment is essential for a range of applications, from environmental testing to food and beverage analysis. Their compatibility with numerous solvents and operating conditions allows researchers to customize their methods, enhancing flexibility in experimental design. The demand for packed columns is expected to remain strong, driven by their widespread use in laboratories and the need for reliable analytical outcomes across various sectors.

Membrane Columns :

Membrane columns are an innovative addition to the size exclusion chromatographic columns market, utilizing semi-permeable membranes as the stationary phase for separation. These columns are particularly advantageous for applications that require the separation of smaller molecules from larger ones, such as in the purification of proteins or the desalting of samples. The ability of membrane columns to achieve high selectivity and efficiency in separation processes positions them as a valuable tool in both research and industrial applications. Their growing recognition in bioprocessing and environmental monitoring is anticipated to enhance their market presence as researchers increasingly focus on sustainable and efficient separation methods.

By Application

Pharmaceutical & Biotechnology :

The pharmaceutical and biotechnology applications of size exclusion chromatographic columns are central to the market's growth, as they are critical for drug development and quality control processes. In these sectors, accuracy and reliability are paramount, necessitating advanced chromatographic techniques that ensure the integrity of complex biomolecules. The size exclusion method is particularly favored for its ability to separate proteins, peptides, and nucleic acids without denaturing them, making it ideal for formulating biologics. As the number of biopharmaceutical products on the market increases, the demand for effective purification and analysis methods will drive further growth in this application segment.

Food & Beverage :

In the food and beverage industry, size exclusion chromatographic columns play a crucial role in quality assurance and compliance with safety regulations. These columns are employed to analyze food components, detect contaminations, and quantify additives, ensuring that products meet the required standards before reaching consumers. The increasing emphasis on food safety and regulatory compliance has heightened the need for sophisticated analytical techniques, including size exclusion chromatography. As more food and beverage companies recognize the importance of maintaining high-quality standards, demand for size exclusion chromatographic columns is expected to rise steadily in this sector.

Environmental Analysis :

Environmental analysis is another significant application of size exclusion chromatographic columns, particularly in the monitoring and assessment of pollutants in water and soil. With growing concerns over environmental sustainability and the safety of natural resources, the need for effective analytical techniques to detect contaminants is paramount. Size exclusion chromatography is utilized to separate and quantify various substances, such as heavy metals, organic compounds, and microplastics. The rising awareness of environmental issues is prompting governments and industries to invest in advanced analytical solutions, thereby driving demand for size exclusion chromatographic columns in this application area.

Academic Research :

Academic research serves as a foundational application for size exclusion chromatographic columns, as universities and research institutions seek to advance knowledge in various scientific fields. These columns are integral to numerous studies involving the separation and characterization of biomolecules, making them essential tools in laboratories. The growth of academic research funding, along with the increasing number of research projects focusing on drug discovery and materials science, is anticipated to bolster the demand for size exclusion chromatographic columns. As collaboration between academic institutions and industries continues to grow, the relevance of these columns in research will only increase.

Others :

Other applications of size exclusion chromatographic columns encompass a diverse range of sectors, including cosmetics, agriculture, and diagnostics. These columns are employed to analyze complex formulations, assess product safety, and verify the efficacy of agricultural products. As companies across various industries recognize the benefits of size exclusion chromatography for quality control and research purposes, the market for this application segment is expected to expand. The versatility of size exclusion chromatographic columns in adapting to different analytical needs and regulations will also contribute to growth in this area.

By Distribution Channel

Online Stores :

The rise of e-commerce has significantly impacted the distribution of size exclusion chromatographic columns, with online stores becoming a prominent channel for purchasing these products. The convenience of online shopping allows laboratories and researchers to access a wide variety of columns from global suppliers without geographical limitations. Furthermore, online platforms often provide detailed product information, customer reviews, and competitive pricing, enabling buyers to make informed decisions. As online shopping continues to gain traction, the market share of size exclusion chromatographic columns through this channel is expected to grow, driven by increased accessibility and the ability to compare options easily.

Specialty Stores :

Specialty stores cater specifically to the needs of laboratories and researchers, making them an important distribution channel for size exclusion chromatographic columns. These stores typically offer a curated selection of high-quality products and specialized support services, such as technical assistance and product advice. The expertise provided by specialty stores can help researchers select the right columns for their specific applications, enhancing user satisfaction and performance outcomes. As laboratories increasingly prioritize quality and service, the role of specialty stores in distributing size exclusion chromatographic columns is expected to remain vital.

Direct Sales :

Direct sales channels represent another crucial avenue for the distribution of size exclusion chromatographic columns. Manufacturers often engage in direct sales to establish close relationships with customers, allowing for tailored solutions and technical support. This approach enhances customer loyalty and ensures that researchers have access to the latest innovations and product offerings. As the demand for size exclusion chromatographic columns grows, manufacturers are likely to expand their direct sales efforts to better serve their clientele, fostering a more personalized purchasing experience.

Distributors :

Distributors play a key role in the supply chain of size exclusion chromatographic columns by connecting manufacturers with end-users. These distribution partners typically have established relationships and networks within various industries, facilitating the efficient delivery of products. Distributors often carry a broad range of products, ensuring that laboratories can find the right chromatographic solutions to meet their needs. As industries continue to evolve and require advanced separation technologies, the role of distributors in the size exclusion chromatographic columns market will be paramount in ensuring product availability and timely support.

By Material Type

Silica-based :

Silica-based materials are among the most commonly used in size exclusion chromatographic columns due to their excellent separation capabilities and chemical stability. These materials provide a solid stationary phase that allows for effective separation of various biomolecules based on size. The versatility of silica-based columns makes them suitable for a wide range of applications, from pharmaceuticals to food analysis. As researchers seek to optimize their separation processes, silica-based columns remain a favored choice, driving their growth in the market. Additionally, advancements in silica technology continue to enhance performance, contributing to the sustained demand for these materials.

Polymer-based :

Polymer-based materials are gaining traction in the size exclusion chromatographic columns market due to their unique properties, such as flexibility and lower density. These materials offer advantages in specific applications, particularly for separating biomolecules sensitive to the harsh conditions often associated with silica-based columns. Polymer-based columns are commonly used in bioprocessing and biomedical research, where gentle separation is crucial for maintaining the integrity of sensitive samples. As the demand for diverse separation techniques increases, polymer-based chromatographic columns are expected to capture a larger share of the market.

Metal-based :

Metal-based chromatographic columns represent a specialized segment within the size exclusion market, primarily utilized for applications that require high pressure and temperature stability. These columns are often employed in advanced research and industrial settings, where durability and robustness are paramount. The growing interest in high-performance liquid chromatography (HPLC) is driving the demand for metal-based columns, as they can withstand rigorous conditions while providing reliable results. As the need for analytical precision in various sectors grows, metal-based chromatographic columns are expected to see increased adoption.

Glass-based :

Glass-based columns are revered for their chemical inertness and clarity, making them an essential choice in laboratories that require high visibility and resistance to contamination. These columns are often employed in educational settings and foundational research, where accurate observations and precise measurements are critical. Additionally, glass-based columns allow for easy monitoring of the separation process, enhancing the user experience. As educational institutions and research facilities continue to prioritize quality and accuracy, the demand for glass-based size exclusion chromatographic columns is expected to persist.

Others :

The "Others" category in material types encompasses various specialized materials and innovative composites developed to enhance chromatographic performance. This segment includes novel materials designed to meet specific analytical needs, such as biomimetic materials or those engineered for high selectivity. As scientists explore new frontiers in separation science, the development and adoption of these innovative materials are anticipated to grow. The demand for customized solutions that cater to unique research requirements will drive the expansion of this category, contributing to the overall growth of the size exclusion chromatographic columns market.

By Region

The North American region is anticipated to dominate the size exclusion chromatographic columns market, accounting for approximately 35% of the global market share by 2035. The well-established pharmaceutical and biotechnology sectors, combined with extensive research and development activities, are key contributors to this growth. The presence of major industry players and academic institutions further solidifies North America's leading position in the market. Additionally, the growing focus on drug safety and quality assurance in this region is expected to enhance the adoption of size exclusion chromatography as a standard analytical method. The CAGR for the North American market is projected to be around 6.5%, reflecting robust growth opportunities in this region.

In Europe, the size exclusion chromatographic columns market is predicted to hold a significant share, estimated at about 28% of the global market. The region is characterized by stringent regulatory frameworks that require accurate analytical methods in pharmaceuticals and environmental monitoring. Additionally, the rising emphasis on food safety and quality control in Europe has prompted increased adoption of chromatographic techniques, including size exclusion chromatography. The European market is expected to witness a CAGR of around 5.8%, driven by ongoing investments in biotechnology and academic research initiatives across the region. As European industries prioritize analytical accuracy and compliance, the demand for size exclusion chromatographic columns will continue to grow.

Opportunities

The size exclusion chromatographic columns market is rife with opportunities that can be leveraged to drive growth and innovation. One of the most significant opportunities lies in the increase in global investment in research and development, particularly within the pharmaceutical and biotechnology industries. As companies strive to discover and develop new therapeutic modalities, there will be an escalating demand for reliable and efficient separation technologies to support these endeavors. Furthermore, the rising trend of personalized medicine necessitates advanced analytical techniques to ensure the safety and efficacy of tailored treatments. This growing focus on precision in healthcare will inevitably fuel the adoption of size exclusion chromatography, creating a favorable market environment.

Moreover, the expansion of emerging markets in Asia-Pacific and Latin America presents a compelling opportunity for growth in the size exclusion chromatographic columns market. As these regions witness rapid industrialization and investments in research infrastructure, the demand for advanced analytical tools will escalate. This shift will likely result in increased usage of chromatographic techniques across various sectors, including pharmaceuticals, food safety, and environmental monitoring. Companies that strategically position themselves to tap into these burgeoning markets stand to gain significant advantages in terms of market share and innovation. The increasing collaboration between industry stakeholders and research institutions will also foster advancements in chromatographic technologies, further enhancing opportunities for growth in this sector.

Threats

Despite the promising growth prospects within the size exclusion chromatographic columns market, several threats could impede its expansion. One major concern is the rapid pace of technological advancements, which necessitates continuous innovation and adaptation from manufacturers. Companies that fail to keep up with the latest trends and developments may find themselves lagging behind competitors who are better equipped to meet evolving customer needs. Additionally, the emergence of alternative separation techniques could pose a threat to size exclusion chromatography, especially if these alternatives provide superior performance or cost advantages. The increasing pressure to reduce research and production costs may also force some organizations to seek less expensive or less sophisticated analytical solutions, potentially impacting the demand for size exclusion chromatographic columns.

Another potential challenge is the regulatory landscape surrounding the use of chromatographic techniques, which can vary significantly across different regions and industries. Stricter regulations may complicate the approval process for new products or technologies, thereby stifling innovation and slowing market growth. Additionally, the ongoing global economic uncertainties, including fluctuating currency exchange rates and geopolitical tensions, could hinder investment in research and development initiatives, ultimately affecting the size exclusion chromatographic columns market. Companies must remain vigilant and adaptable to these threats, ensuring they are prepared to navigate the evolving marketplace.

Competitor Outlook

• Agilent Technologies
• Thermo Fisher Scientific
• Merck KGaA
• Waters Corporation
• GE Healthcare
• Pall Corporation
• Bio-Rad Laboratories
• PerkinElmer Inc.
• Repligen Corporation
• Phenomenex
• Shimadzu Corporation
• Jasco Corporation
• Sigma-Aldrich (part of Merck Group)
• VWR International (part of Avantor)
• Macherey-Nagel

The competitive landscape of the size exclusion chromatographic columns market is characterized by the presence of several prominent players that dominate the market through innovation and strategic partnerships. Major companies such as Agilent Technologies and Thermo Fisher Scientific are continually investing in research and development, striving to improve their product offerings and expand their market reach. These companies leverage their technological expertise and extensive distribution networks to establish a strong foothold in both established and emerging markets. Additionally, many of these firms are actively pursuing mergers and acquisitions to enhance their product portfolios and gain access to new technologies.

Waters Corporation and Merck KGaA are other key players that have made significant contributions to the advancement of size exclusion chromatography technologies. Waters Corporation, known for its high-performance liquid chromatography (HPLC) systems, has integrated size exclusion chromatography into its product range to cater to the diverse needs of researchers. Similarly, Merck KGaA has focused on enhancing its chromatographic products by developing innovative materials and technologies that improve separation efficiencies. The emphasis on sustainability and environmentally friendly practices is also becoming a priority for many players, leading to the development of greener chromatographic solutions that align with current industry trends.

Additionally, companies like Bio-Rad Laboratories and GE Healthcare are focusing on expanding their presence in specific application areas such as biotechnology and pharmaceuticals. These organizations are continually looking for ways to optimize their chromatographic processes and improve the performance of their columns. By addressing the unique challenges faced by researchers in these sectors, they are well-positioned to capture market share and build strong customer loyalty. As the size exclusion chromatographic columns market continues to grow, maintaining a competitive edge will require ongoing innovation and responsiveness to the evolving needs of customers.

• 1 Appendix

  • 1.1 List of Tables
  • 1.2 List of Figures

• 2 Introduction

  • 2.1 Market Definition
  • 2.2 Scope of the Report
  • 2.3 Study Assumptions
  • 2.4 Base Currency & Forecast Periods

• 3 Market Dynamics

  • 3.1 Market Growth Factors
  • 3.2 Economic & Global Events
  • 3.3 Innovation Trends
  • 3.4 Supply Chain Analysis

• 4 Consumer Behavior

  • 4.1 Market Trends
  • 4.2 Pricing Analysis
  • 4.3 Buyer Insights

• 5 Key Player Profiles

  • 5.1 Merck KGaA
    • 5.1.1 Business Overview
    • 5.1.2 Products & Services
    • 5.1.3 Financials
    • 5.1.4 Recent Developments
    • 5.1.5 SWOT Analysis
  • 5.2 Phenomenex
    • 5.2.1 Business Overview
    • 5.2.2 Products & Services
    • 5.2.3 Financials
    • 5.2.4 Recent Developments
    • 5.2.5 SWOT Analysis
  • 5.3 GE Healthcare
    • 5.3.1 Business Overview
    • 5.3.2 Products & Services
    • 5.3.3 Financials
    • 5.3.4 Recent Developments
    • 5.3.5 SWOT Analysis
  • 5.4 Macherey-Nagel
    • 5.4.1 Business Overview
    • 5.4.2 Products & Services
    • 5.4.3 Financials
    • 5.4.4 Recent Developments
    • 5.4.5 SWOT Analysis
  • 5.5 Pall Corporation
    • 5.5.1 Business Overview
    • 5.5.2 Products & Services
    • 5.5.3 Financials
    • 5.5.4 Recent Developments
    • 5.5.5 SWOT Analysis
  • 5.6 PerkinElmer Inc.
    • 5.6.1 Business Overview
    • 5.6.2 Products & Services
    • 5.6.3 Financials
    • 5.6.4 Recent Developments
    • 5.6.5 SWOT Analysis
  • 5.7 Jasco Corporation
    • 5.7.1 Business Overview
    • 5.7.2 Products & Services
    • 5.7.3 Financials
    • 5.7.4 Recent Developments
    • 5.7.5 SWOT Analysis
  • 5.8 Waters Corporation
    • 5.8.1 Business Overview
    • 5.8.2 Products & Services
    • 5.8.3 Financials
    • 5.8.4 Recent Developments
    • 5.8.5 SWOT Analysis
  • 5.9 Agilent Technologies
    • 5.9.1 Business Overview
    • 5.9.2 Products & Services
    • 5.9.3 Financials
    • 5.9.4 Recent Developments
    • 5.9.5 SWOT Analysis
  • 5.10 Bio-Rad Laboratories
    • 5.10.1 Business Overview
    • 5.10.2 Products & Services
    • 5.10.3 Financials
    • 5.10.4 Recent Developments
    • 5.10.5 SWOT Analysis
  • 5.11 Repligen Corporation
    • 5.11.1 Business Overview
    • 5.11.2 Products & Services
    • 5.11.3 Financials
    • 5.11.4 Recent Developments
    • 5.11.5 SWOT Analysis
  • 5.12 Shimadzu Corporation
    • 5.12.1 Business Overview
    • 5.12.2 Products & Services
    • 5.12.3 Financials
    • 5.12.4 Recent Developments
    • 5.12.5 SWOT Analysis
  • 5.13 Thermo Fisher Scientific
    • 5.13.1 Business Overview
    • 5.13.2 Products & Services
    • 5.13.3 Financials
    • 5.13.4 Recent Developments
    • 5.13.5 SWOT Analysis
  • 5.14 Sigma-Aldrich (part of Merck Group)
    • 5.14.1 Business Overview
    • 5.14.2 Products & Services
    • 5.14.3 Financials
    • 5.14.4 Recent Developments
    • 5.14.5 SWOT Analysis
  • 5.15 VWR International (part of Avantor)
    • 5.15.1 Business Overview
    • 5.15.2 Products & Services
    • 5.15.3 Financials
    • 5.15.4 Recent Developments
    • 5.15.5 SWOT Analysis

• 6 Market Segmentation

  • 6.1 Size Exclusion Chromatographic Columns Market, By Application
    • 6.1.1 Pharmaceutical & Biotechnology
    • 6.1.2 Food & Beverage
    • 6.1.3 Environmental Analysis
    • 6.1.4 Academic Research
    • 6.1.5 Others
  • 6.2 Size Exclusion Chromatographic Columns Market, By Product Type
    • 6.2.1 Porous Columns
    • 6.2.2 Gel Filtration Columns
    • 6.2.3 Monolithic Columns
    • 6.2.4 Packed Columns
    • 6.2.5 Membrane Columns
  • 6.3 Size Exclusion Chromatographic Columns Market, By Material Type
    • 6.3.1 Silica-based
    • 6.3.2 Polymer-based
    • 6.3.3 Metal-based
    • 6.3.4 Glass-based
    • 6.3.5 Others
  • 6.4 Size Exclusion Chromatographic Columns Market, By Distribution Channel
    • 6.4.1 Online Stores
    • 6.4.2 Specialty Stores
    • 6.4.3 Direct Sales
    • 6.4.4 Distributors

• 7 Competitive Analysis

  • 7.1 Key Player Comparison
  • 7.2 Market Share Analysis
  • 7.3 Investment Trends
  • 7.4 SWOT Analysis

• 8 Research Methodology

  • 8.1 Analysis Design
  • 8.2 Research Phases
  • 8.3 Study Timeline

• 9 Future Market Outlook

  • 9.1 Growth Forecast
  • 9.2 Market Evolution

• 10 Geographical Overview

  • 10.1 Europe - Market Analysis
    • 10.1.1 By Country
      • 10.1.1.1 UK
      • 10.1.1.2 France
      • 10.1.1.3 Germany
      • 10.1.1.4 Spain
      • 10.1.1.5 Italy
  • 10.2 Asia Pacific - Market Analysis
    • 10.2.1 By Country
      • 10.2.1.1 India
      • 10.2.1.2 China
      • 10.2.1.3 Japan
      • 10.2.1.4 South Korea
  • 10.3 Latin America - Market Analysis
    • 10.3.1 By Country
      • 10.3.1.1 Brazil
      • 10.3.1.2 Argentina
      • 10.3.1.3 Mexico
  • 10.4 North America - Market Analysis
    • 10.4.1 By Country
      • 10.4.1.1 USA
      • 10.4.1.2 Canada
  • 10.5 Middle East & Africa - Market Analysis
    • 10.5.1 By Country
      • 10.5.1.1 Middle East
      • 10.5.1.2 Africa
  • 10.6 Size Exclusion Chromatographic Columns Market by Region

• 11 Global Economic Factors

  • 11.1 Inflation Impact
  • 11.2 Trade Policies

• 12 Technology & Innovation

  • 12.1 Emerging Technologies
  • 12.2 AI & Digital Trends
  • 12.3 Patent Research

• 13 Investment & Market Growth

  • 13.1 Funding Trends
  • 13.2 Future Market Projections

• 14 Market Overview & Key Insights

  • 14.1 Executive Summary
  • 14.2 Key Trends
  • 14.3 Market Challenges
  • 14.4 Regulatory Landscape

Segments Analyzed in the Report

The global Size Exclusion Chromatographic Columns market is categorized based on

By Product Type

• Porous Columns
• Gel Filtration Columns
• Monolithic Columns
• Packed Columns
• Membrane Columns

By Application

• Pharmaceutical & Biotechnology
• Food & Beverage
• Environmental Analysis
• Academic Research
• Others

By Distribution Channel

• Online Stores
• Specialty Stores
• Direct Sales
• Distributors

By Material Type

• Silica-based
• Polymer-based
• Metal-based
• Glass-based
• Others

By Region

• North America
• Europe
• Asia Pacific
• Latin America
• Middle East & Africa

Key Players

• Agilent Technologies
• Thermo Fisher Scientific
• Merck KGaA
• Waters Corporation
• GE Healthcare
• Pall Corporation
• Bio-Rad Laboratories
• PerkinElmer Inc.
• Repligen Corporation
• Phenomenex
• Shimadzu Corporation
• Jasco Corporation
• Sigma-Aldrich (part of Merck Group)
• VWR International (part of Avantor)
• Macherey-Nagel